What are the Differences Between AL-LAD and LSD-25?

AL-LAD is a compound that is similar to LSD in structure and psychedelic effect. It is known by several names, including 6-allyl-6-nor-LSD and N-allyl-nor-LSD. In this article, we discuss the differences between LSD and AL-LAD.

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It's always a good idea to test your substance before using it. Buy reagent tests at Elevation Chemicals. Learn more about reagent testing for LSD and its analogs here at Explore Psychedelics.

Chemical structure

The compound AL-LAD was originally discovered by Albert Hoffman in his work synthesizing LSD analogs. AL-LAD is very similar to LSD structurally. Both LSD and AL-LAD include an indole group. The only difference is AL-LAD has an allyl group attached to the indole while LSD has a methyl group.

Psychoactive Effects

One of the first papers describing the synthesis of AL-LAD also examined its potency compared to LSD.1 To do this, the researchers exposed rats to various doses of LSD and trained them to push a lever if they could detect an effect. They found that rats were able to detect AL-LAD at under half the dose of LSD. This suggests that AL-LAD is significantly more potent than LSD in this animal model.

There is only one scientific paper describing the effect of AL-LAD on humans.2 In this work, researchers combined the reports of multiple LSD analogs. They found that LSD analogs as a group, including AL-LAD, have a significantly weaker strength, pleasurable high and comedown as compared to LSD.

Despite these animal experiments, anecdotal reports of AL-LAD from human usage do not support such a large difference. Reports from users indicate that it takes a roughly similar dosage, if not more, to LSD to get a similar effect.3456 These recreational users generally describe that the cognitive and physical effects of AL-LAD happen more quickly than LSD, with the entire experience lasting a shorter amount of time. Because of this, some people regard AL-LAD as more recreationally accessible than LSD because of the shorter duration.

Side effects / health risks

There is little scientific or medical research on the health effects of AL-LAD on humans. It is generally regarded to be similar to LSD in that higher doses can cause stronger reactions, but generally not rising to the level of requiring medical attention.

The physical body effects of AL-LAD are similar to LSD according to anecdotal reports from users.36

Biological mechanism of action

Because AL-LAD is similar in structure to LSD, it is thought that it functions through the same mechanism of activating serotonin receptors. Similar to many of the analogs that are closely related to LSD, it is thought that AL-LAD undergoes a reaction after consumption that converts some portion of it to LSD. This would make AL-LAD a prodrug of LSD. If this is the case, both LSD and AL-LAD would be expected to produce a nearly identical effect.

Various animal models have been used to study the effect of AL-LAD. Rats that have been trained on LSD, cannot discriminate the effect of AL-LAD other than by dosage.1 Similarly, mice that are treated with LSD or AL-LAD exhibit the same head-twitching in response to either compound.7 The similarity in effect between AL-LAD and LSD suggests that these two chemicals function using the same biological mechanisms.

Reagent Tests

Both the Ehrlich and Marquis reagent tests are commonly used when testing for the presence of AL-LAD.

The Ehrlich reagent test determines if a chemical has a structure called an indole. Like many LSD analogs, AL-LAD has an indole in its structure, which leads to a positive test result. Because of this, AL-LAD, LSD and many other LSD analogs are expected to test positive. This test therefore cannot determine if a sample is AL-LAD or any other chemical that includes an indole. As with other analogs that have large structures attached to an LSD backbone, it is expected that AL-LAD may take longer for the test to return a positive result compared to LSD. This is because the additional chemical groups need to be removed before the indole structure is exposed, or may make the indole structure less accessible. In general, the Ehrlich test is used to rule out research chemicals that may be passed off as LSD but are not closely related, such as 25I-NBOMe.

The Marquis reagent test is also commonly used with samples of AL-LAD. This test is useful for checking for the presences of compounds like meth, MDMA and bath salts. AL-LAD is not expected to react in any way with the Marquis test chemically.8 In agreement, the US Department of Justice has published a standards guide that does not include AL-LAD as a possible reactant for the Marquis reagent test.9 Practically, this reagent test is not used to determine if a sample has AL-LAD or LSD. Instead it is used to determine if other unwanted chemicals are present in the sample being tested.

Various more advanced laboratory techniques exist that can determine if a substance is AL-LAD, including mass spectrometry and liquid chromatography. These techniques are highly accurate but make use of specialized laboratory equipment and are not generally available to the public.

In the United States, AL-LAD is not a controlled substance. Similar to other LSD-like compounds, it is possible to purchase AL-LAD as a research chemical as long as it is not used for human consumption.

However, due to the similar structure and possible biological mechanism, it is possible that AL-LAD could be prosecuted under the Federal Analogue Act. 10 Several countries have specifically banned AL-LAD specifically, including Denmark11, Sweden12, Switzerland13 and the UK14.

For more information on the legal status of LSD analogs, read our other article.

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